5-AMINO-1MQ

5-Amino-1MQ: Selective NNMT Inhibition and Metabolic Research

When researchers look to buy 5-Amino-1MQ, they are seeking a specialized small molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme predominantly expressed in adipose tissue and the liver, where it plays a critical role in cellular energy homeostasis and metabolic signaling. Procuring high-purity 5-Amino-1MQ is essential for investigating how the suppression of NNMT can influence intracellular levels of NAD+ and S-adenosyl-L-methionine (SAM), potentially reversing diet-induced obesity and improving insulin sensitivity in research models.

Technical Specifications

• Molecular Formula: $C_{10}H_{11}N_2$ (as a free base) or $C_{10}H_{11}IN_2$ (as an iodide salt).

• Molecular Weight: 159.21 g/mol (free base) or 286.11 g/mol (iodide salt).

• Purity: ≥98% (HPLC Tested).

• Mechanism of Action: Competitive, membrane-permeable small molecule inhibitor of NNMT.

• Format: Lyophilized powder, often appearing as a faint red to dark brown solid.

• Solubility: Soluble in DMSO (2 mg/mL).

• Storage: Store desiccated at -20°C for long-term stability.

Research Applications: Why Buy 5-Amino-1MQ?

For those investigating the utility of this molecule, 5-Amino-1MQ is a primary tool for studying immunometabolism and cellular aging. Researchers often buy 5-Amino-1MQ online to analyze its capacity to:

• Promote Lipolysis: By inhibiting NNMT, researchers observe a reduction in white adipose tissue mass and a suppression of lipogenesis in adipocyte models.

• Enhance Muscle Regeneration: Studies in aged mice suggest that 5-Amino-1MQ can improve muscle stem cell (satellite cell) proliferation and regeneration, leading to enhanced grip strength and endurance.

• Elevate NAD+ Levels: Inhibition of NNMT prevents the depletion of nicotinamide, thereby increasing the availability of precursors for the NAD+ salvage pathway.

• Address Mitochondrial Dysfunction: Emerging research explores its role in improving mitochondrial efficiency and reducing oxidative stress associated with cellular senescence.

Strategic Sourcing and Global Logistics

For laboratories searching to buy 5-Amino-1MQ online, finding a supplier that offers secure international shipping with full analytical documentation is paramount. As a small molecule with high membrane permeability, ensuring the chemical stability of the iodide salt during transit is critical for reproducible results in metabolic assays. We provide a verified high-purity guarantee for all research materials. Whether you are conducting research in the USA, UK, Canada, or Australia, our logistics network ensures your materials arrive with the analytical precision your research demands.

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Intended Use:

This compound is intended strictly for in vitro laboratory research. It is not approved for human or animal administration and must not be used in food, dietary supplements, cosmetics, or pharmaceuticals.

Legal Disclaimer:

This product and related information have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, cure, or prevention of any disease. Use is restricted to qualified research professionals in certified laboratory environments.

Terms of Sale:

By purchasing from Mile High Compounds, the buyer affirms they are a qualified researcher or institution, fully responsible for lawful handling, storage, and research use of this material. All sales are final.