Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-10), specifically incorporating the ACTH(4-7) core sequence with a stabilizing C-terminal Pro-Gly-Pro tripeptide. It has been studied in cellular biology, neurobiology, and biochemical research literature examining melanocortin receptor interactions, neurotrophic factor expression (including BDNF pathways), monoaminergic signaling, and neuroprotective mechanisms in experimental models.
Each bottle contains 50mg of Semax in a ready-to-use spray formulation within a sealed 30mL bottle delivering approximately 200 metered sprays, verified through Mile High Compounds’ three-tier quality protocol: 7x independent third-party analytical testing, 4-vial (or multi-unit) batch conformity verification, and comprehensive heavy metal screening.
Product Specifications
Compound: Semax (Met-Glu-His-Phe-Pro-Gly-Pro)
Class: Synthetic heptapeptide / ACTH(4-10) analog
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Weight: ~813.9 Da
Form: Ready-to-use aqueous spray solution
Bottle Size: 50mg total in 30mL bottle (~200 sprays)
Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)
Research Background
Semax has been investigated in research literature across several scientific contexts:
Melanocortin receptor and ACTH fragment research — studies examining receptor interactions and cellular signaling pathways involving the ACTH/α-MSH peptide family without corticotropic activity
Neurotrophic factor pathway research — investigations into modulation of BDNF and related signaling in hippocampal and cortical models
Monoaminergic system research — studies on dopaminergic and serotonergic parameters in rodent models
Neuroprotective and cellular stress response research — examination of effects in experimental ischemia, oxidative stress, and gene expression models
Short-chain peptide chemistry and structure-activity research — analytical and comparative studies on ACTH-derived peptides and stabilizing modifications
Semax is notable in research literature as a stabilized synthetic analog designed to retain the neuroactive properties of the ACTH(4-7) fragment while enhancing metabolic stability via the Pro-Gly-Pro extension. Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies on Semax and related ACTH/melanocortin peptide research.
Analytical Verification
Every batch undergoes Mile High Compounds’ comprehensive analytical protocol:
High-Performance Liquid Chromatography (HPLC) for purity quantification
Mass Spectrometry (MS) for molecular weight and identity confirmation
14-day sterility testing
Endotoxin analysis
Multi-unit batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-unit sampling approach
Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
Container and seal integrity verification
Batch-specific Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.
Storage and Handling
Storage: Cool, dry location away from direct light; refrigerate at 2-8°C for optimal stability
Protect from light and excessive heat
Avoid: Freezing or prolonged exposure to elevated temperatures to preserve compound stability and solution integrity
Use within the labeled period after first opening for optimal research integrity
Quality Standards
Mile High Compounds maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.
7x independent third-party testing per batch
Multi-unit batch conformity verification
Heavy metal screening for trace contaminant analysis
cGMP-compliant manufacturing
Full analytical traceability
Same-day shipping for orders placed before 3PM MST
Terms of Sale
This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Mile High Compounds assumes no liability for misuse or off-label application.
About Mile High Compounds
Colorado-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, multi-unit batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant facilities.
Trusted by the research community with 4.9-star Trustpilot & PepReviewPro ratings and over 700+ verified customer reviews.
Reviews
There are no reviews yet.