ARA-290

ARA-290 (Cibinetide): Target Receptor Signaling for Tissue Repair

When researchers look to buy ARA-290, they are seeking Cibinetide, a synthetic 11-amino-acid peptide modeled from the three-dimensional structure of the helix-B surface of erythropoietin (EPO). ARA-290 is highly valued in neurological and metabolic research because it isolates EPO’s potent anti-inflammatory and tissue-protective properties without stimulating erythropoiesis (red blood cell production). Procuring high-purity ARA-290 peptide is critical for investigating cellular survival mechanisms, neuropathic pain pathways, and small nerve fiber regeneration without the confounding thrombotic risks of standard recombinant EPO.

Technical Specifications

• Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (also designated as Pyr-EQLERALNSS-OH)

• Molecular Formula: $C_{51}H_{84}N_{16}O_{21}$

• Molecular Weight: 1257.32 g/mol

• Purity: ≥99% (HPLC Tested)

• Format: Lyophilized White Powder

• Validation: 3rd Party Laboratory COA Included

• Storage: Store desiccated at -20°C for long-term molecular stability.

Research Applications: Why Buy ARA-290?

For those investigating the utility of this compound, ARA-290 serves as a selective agonist for the Innate Repair Receptor (IRR), a heterocomplex consisting of the erythropoietin receptor and the $\beta$-common receptor ($\text{EPOR/}\beta\text{cR}$). Researchers often buy ARA-290 online to explore its therapeutic potential in a wide range of pathological models:

• Neuropathic Pain and SFN: Investigated for its ability to suppress spinal cord microglia activation and stimulate small nerve fiber regrowth in models of sarcoidosis and diabetic small fiber neuropathy (SFN)

• Cardiovascular and Renal Protection: Studied in models of ischemia-reperfusion injury to observe how IRR activation attenuates tissue damage, reduces apoptosis, and dampens systemic inflammation.

• Islet Cell Transplantation: Research indicates ARA-290 can inhibit macrophage activation, protecting transplanted pancreatic islet cells from inflammatory destruction and improving engraftment outcomes in metabolic models.

• Autoimmune Modulation: Explored for its capacity to downregulate proinflammatory cytokines (such as $\text{TNF-}\alpha$ and $\text{IL-6}$) in experimental colitis and lupus models.

Strategic Sourcing and Global Logistics

For laboratories searching to buy ARA-290 online, finding a supplier that provides verified 99%+ purity is essential to ensure that sensitive assays evaluating cell survival and nerve regeneration are not disrupted by synthesis artifacts. We provide comprehensive analytical documentation, including HPLC and MS verification, with every order. Whether your laboratory is based in the USA, UK, Canada, or Australia, our logistics network ensures that your lyophilized peptides are shipped securely to preserve maximum biological activity.

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Intended Use:

This compound is intended strictly for in vitro laboratory research. It is not approved for human or animal administration and must not be used in food, dietary supplements, cosmetics, or pharmaceuticals.

Legal Disclaimer:

This product and related information have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, cure, or prevention of any disease. Use is restricted to qualified research professionals in certified laboratory environments.

Terms of Sale:

By purchasing from Mile High Compounds, the buyer affirms they are a qualified researcher or institution, fully responsible for lawful handling, storage, and research use of this material. All sales are final.